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1

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[ c ][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc-Max Dimerization

Chauhan, Jay, Wang, Huabo, Yap, Jeremy L., Sabato, Philip E., Hu, Angela, Prochownik, Edward V., Fletcher, Steven

Journal:

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

2

Establishment of an apoptosis-resistant and growth-controllable cell line by transfecting with inducible antisense c-Jun gene

Yon Hui Kim, Takehiro Iida, Tetsuo Fujita, Satoshi Terada, Atsushi Kitayama, Hiroshi Ueda, Edward V. Prochownik, Eiji Suzuki

Journal:

Biotechnology and Bioengineering

Year:

1998

Language:

english

File:

PDF, 186 KB

english, 1998

3

Commonly occurring loss and mutation of the MXI1 gene in prostate cancer

Edward V. Prochownik, Linette Eagle Grove, Debra Deubler, Xiao Lin Zhu, Robert A. Stephenson, L. Ralph Rohr, Xiaoying Yin, Arthur R. Brothman

Journal:

Genes, Chromosomes and Cancer

Year:

1998

Language:

english

File:

PDF, 341 KB

english, 1998

4

Endothelial-like cells derived directly from human tumor xenografts

Gangadharan B. Sajithlal, Terence F. McGuire, Jie Lu, Donna Beer-Stolz, Edward V. Prochownik

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 718 KB

english, 2010

5

A Rapid Method for the Preparation of Yeast Lysates That Facilitates the Immunodetection of Proteins Generated by the Yeast Two-Hybrid System

Kenneth Langlands, Edward V. Prochownik

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 159 KB

english, 1997

6

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Ariele Viacava Follis, Dalia I. Hammoudeh, Huabo Wang, Edward V. Prochownik, Steven J. Metallo

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 511 KB

english, 2008

7

Permanently Blocked Stem Cells Derived From Breast Cancer Cell Lines

Gangadharan B. Sajithlal, Kristi Rothermund, Fang Zhang, David J. Dabbs, Jean J. Latimer, Stephen G. Grant, Edward V. Prochownik

Journal:

Year:

2010

Language:

english

File:

PDF, 589 KB

english, 2010

8

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

Jianxia Guo, Robert A. Parise, Erin Joseph, Merrill J. Egorin, John S. Lazo, Edward V. Prochownik, Julie L. Eiseman

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 585 KB

english, 2009

9

Inhibition of reverse transcriptases of primate type C viruses by 7S immunoglobulin from patients with leukaemia

PROCHOWNIK, EDWARD V., KIRSTEN, WERNER H.

Journal:

Year:

1976

File:

PDF, 444 KB

1976

10

Nucleic acid sequences of primate type C viruses in normal and neoplastic human tissues

PROCHOWNIK, EDWARD V., KIRSTEN, WERNER H.

Journal:

Year:

1977

File:

PDF, 345 KB

1977

11

Relationship between an enhancer element in the human antithrombin III gene and an immunoglobulin light-chain gene enhancer

Prochownik, Edward V.

Journal:

Year:

1985

File:

PDF, 476 KB

1985

12

Mutation of the MXI1 gene in prostate cancer

Eagle, Linette R., Yin, Xiaoying, Brothman, Arthur R., Williams, Briana J., Atkin, N.B., Prochownik, Edward V.

Journal:

Nature Genetics

Year:

1995

File:

PDF, 761 KB

1995

13

Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc

Gupta, Kalpana, Anand, Geetha, Yin, Xiaoying, Grove, Linette, Prochownik, Edward V

Journal:

Year:

1998

Language:

english

File:

PDF, 489 KB

english, 1998

14

Lack of transcriptional repression by max homodimers

Yin, Xiaoying, Grove, Linette, Prochownik, Edward V

Journal:

Year:

1998

Language:

english

File:

PDF, 1020 KB

english, 1998

15

C-myc overexpression and p53 loss cooperate to promote genomic instability

Yin, XiaoYing, Grove, Linnette, Datta, Nabanita S, Long, Michael W, Prochownik, Edward V

Journal:

Year:

1999

Language:

english

File:

PDF, 276 KB

english, 1999

16

Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms

Elliott, Katherine, Sakamuro, Daitoku, Basu, Amithaba, Du, Wei, Wunner, William, Staller, Peter, Gaubatz, Stefan, Zhang, Hong, Prochownik, Edward, Eilers, Martin

Journal:

Year:

1999

Language:

english

File:

PDF, 675 KB

english, 1999

17

MYC oncogenes and human neoplastic disease

Nesbit, Chadd E, Tersak, Jean M, Prochownik, Edward V

Journal:

Year:

1999

Language:

english

File:

PDF, 200 KB

english, 1999

18

Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network

Yin, Xiao-Ying, Gupta, Kalpana, Han, Wei Ping, Levitan, Edwin S, Prochownik, Edward V

Journal:

Year:

1999

Language:

english

File:

PDF, 732 KB

english, 1999

19

Genetic dissection of c-myc apoptotic pathways

Nesbit, Chadd E, Tersak, Jean M, Grove, Linette E, Drzal, Amy, Choi, Hyunjung, Prochownik, Edward V

Journal:

Year:

2000

Language:

english

File:

PDF, 679 KB

english, 2000

20

Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones

Yin, Xiao-Ying, Grove, Linnette E, Prochownik, Edward V

Journal:

Year:

2001

Language:

english

File:

PDF, 329 KB

english, 2001

21

Dynamic in vivo interactions among Myc network members

Yin, Xiao-ying, Landay, Melanie F, Han, Weiping, Levitan, Edwin S, Watkins, Simon C, Levenson, Richard M, Farkas, Daniel L, Prochownik, Edward V

Journal:

Year:

2001

Language:

english

File:

PDF, 922 KB

english, 2001

22

Low molecular weight inhibitors of Myc–Max interaction and function

Yin, Xiaoying, Giap, Christine, Lazo, John S, Prochownik, Edward V

Journal:

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

23

Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1

Egler, Rachel A, Fernandes, Elaine, Rothermund, Kristi, Sereika, Susan, de Souza-Pinto, Nadja, Jaruga, Pawel, Dizdaroglu, Miral, Prochownik, Edward V

Journal:

Year:

2005

Language:

english

File:

PDF, 372 KB

english, 2005

24

Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt–Mdm2–p53 pathway

Rogulski, Kenneth, Li, Youjun, Rothermund, Kristi, Pu, Lixia, Watkins, Simon, Yi, Fenghua, Prochownik, Edward V

Journal:

Year:

2005

Language:

english

File:

PDF, 863 KB

english, 2005

25

Increased Cell-Substrate Adhesion Accompanies Conditional Reversion to the Normal Phenotype in Ras-Oncogene-Transformed NIH-3T3 Cells

Dale K. Shumaker, Marshall D. Sklar, Edward V. Prochownik, James Varani

Journal:

Experimental Cell Research

Year:

1994

File:

PDF, 704 KB

1994

26

Assignment of the Human MAD and MXI1 Genes to Chromosomes 2p12-p13 and 10q24-q25

David N. Shapiro, Virginia Valentine, Linette Eagle, Xiaoying Yin, Stephan W. Morris, Edward V. Prochownik

Journal:

Year:

1994

File:

PDF, 255 KB

1994

27

Molecular genetics of inherited antithrombin III deficiencies

Edward V. Prochownik

Journal:

The American Journal of Medicine

Year:

1989

Language:

english

File:

PDF, 390 KB

english, 1989

28

Embryonal rhabdomyosarcoma of the ampulla of vater with long-term survival following pancreaticoduodenectomy

Michael G. Caty, Keith T. Oldham, Edward V. Prochownik

Journal:

Journal of Pediatric Surgery

Year:

1990

Language:

english

File:

PDF, 1.32 MB

english, 1990

29

Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

Mustata, Gabriela, Follis, Ariele Viacava, Hammoudeh, Dalia I., Metallo, Steven J., Wang, Huabo, Prochownik, Edward V., Lazo, John S., Bahar, Ivet

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 375 KB

english, 2009

30

Changes in protein kinase C activity are associated with the differentiation of Friend erythroleukemia cells

Kenneth J. Balazovich, Douglas Portnow, Laurence A. Boxer, Edward V. Prochownik

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1987

Language:

english

File:

PDF, 696 KB

english, 1987

31

Protooncogenes and Cell Differentiation

Edward V. Prochownik

Journal:

Transfusion Medicine Reviews

Year:

1989

Language:

english

File:

PDF, 1.72 MB

english, 1989

32

Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein–protein and protein–DNA interactions

Yap, Jeremy L., Chauhan, Jay, Jung, Kwan-Young, Chen, Lijia, Prochownik, Edward V., Fletcher, Steven

Journal:

Year:

2012

Language:

english

File:

PDF, 643 KB

english, 2012

33

Small-molecule inhibitors of the Myc oncoprotein

Fletcher, Steven, Prochownik, Edward V.

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

34

Obituary

Hammoudeh, Dalia, Viachava-Follis, Ariele, Prochownik, Edward V., Metallo, Steven J.

Journal:

Year:

1956

Language:

english

File:

PDF, 697 KB

english, 1956

35

Small Molecule Binding of Intrinsically Disordered Proteins: Multiple Binders on Multiple Sites

Hammoudeh, Dalia, Viachava-Follis, Ariele, Prochownik, Edward V., Metallo, Steven J.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 37 KB

english, 2009

36

Pharmacophore identification of c-Myc inhibitor 10074-G5

Yap, Jeremy L., Wang, Huabo, Hu, Angela, Chauhan, Jay, Jung, Kwan-Young, Gharavi, Robert B., Prochownik, Edward V., Fletcher, Steven

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 502 KB

english, 2013

37

Mechanism of Small-Molecule Binding by Intrinsically Disordered Proteins

Metallo, Steven J., Follis, Ariele Viacava, Hammoudeh, Dalia I., Prochownik, Edward V.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 38 KB

english, 2010

38

Potent Inhibitors Of c-Myc-Max Dimerization Through Multivalent Binding To The Intrinsically Disordered c-Myc Monomer

Follis, Ariele Viacava, Hammoudeh, Dalia, Wang, Huabo, Prochownik, Edward V., Metallo, Steven J.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 70 KB

english, 2009

39

Biology of Marrow Stromal Cell Lines Derived from Long-Term Bone Marrow Cultures of Trp53-Deficient Mice

Michael W. Epperly, Jenifer A. Bray, Timothy M. Carlos, Edward Prochownik and Joel S. Greenberger

Journal:

Radiation Research

Year:

1999

Language:

english

File:

PDF, 1.82 MB

english, 1999

40

Expression and Analysis of COOH-Terminal Deletions of the Human Thrombospondin Molecule

Edward V. Prochownik, Karen O'Rourke and Vishva M. Dixit

Journal:

The Journal of Cell Biology

Year:

1989

Language:

english

File:

PDF, 1.77 MB

english, 1989

41

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

Hammoudeh, Dalia I., Follis, Ariele Viacava, Prochownik, Edward V., Metallo, Steven J.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 1.83 MB

english, 2009

42

Differential Patterns of DNA Binding by myc and max Proteins

Edward V. Prochownik and Mary E. VanAntwerp

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.26 MB

english, 1993

43

c-Myc as a therapeutic target in cancer

Prochownik, Edward V

Journal:

Expert Review of Anticancer Therapy

Year:

2004

Language:

english

File:

PDF, 312 KB

english, 2004

44

c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.:

Edmunds, Lia R., Sharma, Lokendra, Kang, Audry, Lu, Jie, Vockley, Jerry, Basu, Shrabani, Uppala, Radha, Goetzman, Eric S., Beck, Megan E., Scott, Donald, Prochownik, Edward V.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 610 KB

english, 2015

45

c-Myc Is Required for the ChREBP-Dependent Activation of Glucose-Responsive Genes

Zhang, Pili, Metukuri, Mallikarjurna R., Bindom, Sharell M., Prochownik, Edward V., O'Doherty, Robert M., Scott, Donald K.

Journal:

Molecular Endocrinology

Year:

2010

Language:

english

File:

PDF, 647 KB

english, 2010

46

Molecular Heterogeneity of Inherited Antithrombin III Deficiency

Prochownik, Edward V., Antonarakis, Stylianos, Bauer, Kenneth A., Rosenberg, Robert D., Fearon, Eric R., Orkin, Stuart H.

Journal:

Boston Medical and Surgical Journal

Year:

1983

Language:

english

File:

PDF, 3.07 MB

english, 1983

47

c-myc and bcl-2 Modulate p53 Function by Altering p53 Subcellular Trafficking During the Cell Cycle

James J. Ryan, Edward Prochownik, Christopher A. Gottlieb, Ingrid J. Apel, Ramon Merino, Gabriel Nunez and Michael F. Clarke

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.16 MB

english, 1994

48

The Ever Expanding Role for c-Myc in Promoting Genomic Instability

Prochownik, Edward V., Li, Youjun

Journal:

Year:

2007

Language:

english

File:

PDF, 464 KB

english, 2007

49

A Point Mutation in the MyoD Basic Domain Imparts c-Myc-Like Properties

Mary E. Van Antwerp, De Gao Chen, Christina Chang and Edward V. Prochownik

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

50

A Functional Hierarchy for c-Myc Target Genes? Lessons from MT-MC1

Cohen, Debra E., Prochownik, Edward V.

Journal:

Year:

2006

Language:

english

File:

PDF, 184 KB

english, 2006